This article or section refers to elements from one of the Dune computer games.
A large, ballistic, atomic missile that is launched from a designated silo (no road mobile variant is known). The Missile is associated (even recognized as a signature super weapon) with House Harkonnen. The missile is constructed, maintained, and launched from the Palace (of Harkonnen or Sardaukar design) to any place in the battle theater, sending a large powerfull blast with some versions sporting poisonous or radiating "additionals". It is suspected that the missile is a smaller type of a stone burner device (in which if correct would be the proof of Harkonnen's foul play).
The Dune II variant of the Death Hand missile is unimaginably powerful, capable of destroying 6 or more structures, and large quantities of units (even airborne ones), but it's terribly inaccurate and may miss its designated impact zone completely.
The Dune 2000 variant of the Death Hand appears to be bigger, however, its destruction radius is significantly smaller, albeit the firepower of the missile remained more or less the same. In return, the Death Hand became more accurate. The Death Hand requires sufficient power to construct.